Alpha-Synuclein and Calpains Disrupt SNARE-Mediated Synaptic Vesicle Fusion During Manganese Exposure in SH-SY5Y Cells

Synaptic vesicle fusion is mediated by an assembly of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNAREs), composed of syntaxin 1, soluble NSF-attachment protein (SNAP)-25, and synaptobrevin-2/VAMP-2. Previous studies have suggested that over-exposure to manganese...

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Detalles Bibliográficos
Autores principales: Wang, Can, Ma, Zhuo, Yan, Dong-Ying, Liu, Chang, Deng, Yu, Liu, Wei, Xu, Zhao-Fa, Xu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316740/
https://www.ncbi.nlm.nih.gov/pubmed/30544779
http://dx.doi.org/10.3390/cells7120258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316740/
https://www.ncbi.nlm.nih.gov/pubmed/30544779
http://dx.doi.org/10.3390/cells7120258

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