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Alpha-Synuclein and Calpains Disrupt SNARE-Mediated Synaptic Vesicle Fusion During Manganese Exposure in SH-SY5Y Cells

Synaptic vesicle fusion is mediated by an assembly of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNAREs), composed of syntaxin 1, soluble NSF-attachment protein (SNAP)-25, and synaptobrevin-2/VAMP-2. Previous studies have suggested that over-exposure to manganese...

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Detalles Bibliográficos
Autores principales:	Wang, Can, Ma, Zhuo, Yan, Dong-Ying, Liu, Chang, Deng, Yu, Liu, Wei, Xu, Zhao-Fa, Xu, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316740/ https://www.ncbi.nlm.nih.gov/pubmed/30544779 http://dx.doi.org/10.3390/cells7120258

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