Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors

Inhibition of poly(ADP-ribose) polymerase (PARP) activity induces synthetic lethality in mutated BRCA1/2 cancers by selectively targeting tumor cells that fail to repair DNA double strand breaks (DSBs). Clinical studies have confirmed the validity of the synthetic lethality approach and four differe...

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Detalles Bibliográficos
Autores principales: Faraoni, Isabella, Graziani, Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316750/
https://www.ncbi.nlm.nih.gov/pubmed/30518089
http://dx.doi.org/10.3390/cancers10120487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316750/
https://www.ncbi.nlm.nih.gov/pubmed/30518089
http://dx.doi.org/10.3390/cancers10120487

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