SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response

BACKGROUND: The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and m...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Shi-chun, Zhu, Lan, Wang, Yu-xing, Liu, Jie, Zhang, Die, Chen, Yu-lu, Peng, Qing, Liu, Wei, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317191/
https://www.ncbi.nlm.nih.gov/pubmed/30622440
http://dx.doi.org/10.1186/s12935-018-0722-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317191/
https://www.ncbi.nlm.nih.gov/pubmed/30622440
http://dx.doi.org/10.1186/s12935-018-0722-9

Ejemplares similares