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SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response

BACKGROUND: The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and m...

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Detalles Bibliográficos
Autores principales:	Du, Shi-chun, Zhu, Lan, Wang, Yu-xing, Liu, Jie, Zhang, Die, Chen, Yu-lu, Peng, Qing, Liu, Wei, Liu, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317191/ https://www.ncbi.nlm.nih.gov/pubmed/30622440 http://dx.doi.org/10.1186/s12935-018-0722-9

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