Rapid AAV-Neutralizing Antibody Determination with a Cell-Binding Assay

Recombinant adeno-associated virus (rAAV) has been developed as a successful vector for both basic research and human gene therapy. However, neutralizing antibodies (NAbs) against AAV capsids can abolish AAV infectivity on target cells, reducing the transduction efficacy. Absence of AAV NAb has beco...

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Detalles Bibliográficos
Autores principales: Guo, Ping, Zhang, Junping, Chrzanowski, Matthew, Huang, Jianhe, Chew, Helen, Firrman, Jenni A., Sang, Nianli, Diao, Yong, Xiao, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317305/
https://www.ncbi.nlm.nih.gov/pubmed/30623003
http://dx.doi.org/10.1016/j.omtm.2018.11.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317305/
https://www.ncbi.nlm.nih.gov/pubmed/30623003
http://dx.doi.org/10.1016/j.omtm.2018.11.007

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