Cep85 Relays Plk1 Activity to Phosphorylated Nek2A for Its Timely Activation in Centrosome Disjunction

Timely centrosome separation is critical for accurate chromosome separation. It is initiated by Nek2A at the onset of mitosis, but the mechanism for the strict requirement of phosphorylated Nek2A for its own activation remains unclear. In this study, we have found that Plk1 interacts with Cep85 and...

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Detalles Bibliográficos
Autores principales: Chen, Canhe, Xu, Zhenping, Zhang, Ting, Lin, Liping, Lu, Mingke, Xie, Changchuan, Yu, Xianwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317306/
https://www.ncbi.nlm.nih.gov/pubmed/30611117
http://dx.doi.org/10.1016/j.isci.2018.12.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317306/
https://www.ncbi.nlm.nih.gov/pubmed/30611117
http://dx.doi.org/10.1016/j.isci.2018.12.013

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