PRC1 preserves epidermal tissue integrity independently of PRC2

Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable. Loss of PRC1 resulted in blistering skin, reminis...

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Detalles Bibliográficos
Autores principales: Cohen, Idan, Zhao, Dejian, Menon, Gopinathan, Nakayama, Manabu, Koseki, Haruhiko, Zheng, Deyou, Ezhkova, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317312/
https://www.ncbi.nlm.nih.gov/pubmed/30567998
http://dx.doi.org/10.1101/gad.319939.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317312/
https://www.ncbi.nlm.nih.gov/pubmed/30567998
http://dx.doi.org/10.1101/gad.319939.118

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