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PRC1 preserves epidermal tissue integrity independently of PRC2
Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable. Loss of PRC1 resulted in blistering skin, reminis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317312/ https://www.ncbi.nlm.nih.gov/pubmed/30567998 http://dx.doi.org/10.1101/gad.319939.118 |
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author | Cohen, Idan Zhao, Dejian Menon, Gopinathan Nakayama, Manabu Koseki, Haruhiko Zheng, Deyou Ezhkova, Elena |
author_facet | Cohen, Idan Zhao, Dejian Menon, Gopinathan Nakayama, Manabu Koseki, Haruhiko Zheng, Deyou Ezhkova, Elena |
author_sort | Cohen, Idan |
collection | PubMed |
description | Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable. Loss of PRC1 resulted in blistering skin, reminiscent of human skin fragility syndromes. Conversely, PRC1 does not restrict epidermal stratification during skin morphogenesis, whereas PRC2 does. Molecular dissection demonstrated that PRC1 functions with PRC2 to silence/dampen expression of adhesion genes. In contrast, PRC1 promotes expression of critical epidermal adhesion genes independently of PRC2-mediated H3K27me3. Together, we demonstrate a functional link between epigenetic regulation and skin diseases. |
format | Online Article Text |
id | pubmed-6317312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63173122019-07-01 PRC1 preserves epidermal tissue integrity independently of PRC2 Cohen, Idan Zhao, Dejian Menon, Gopinathan Nakayama, Manabu Koseki, Haruhiko Zheng, Deyou Ezhkova, Elena Genes Dev Research Communication Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable. Loss of PRC1 resulted in blistering skin, reminiscent of human skin fragility syndromes. Conversely, PRC1 does not restrict epidermal stratification during skin morphogenesis, whereas PRC2 does. Molecular dissection demonstrated that PRC1 functions with PRC2 to silence/dampen expression of adhesion genes. In contrast, PRC1 promotes expression of critical epidermal adhesion genes independently of PRC2-mediated H3K27me3. Together, we demonstrate a functional link between epigenetic regulation and skin diseases. Cold Spring Harbor Laboratory Press 2019-01-01 /pmc/articles/PMC6317312/ /pubmed/30567998 http://dx.doi.org/10.1101/gad.319939.118 Text en © 2019 Cohen et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Communication Cohen, Idan Zhao, Dejian Menon, Gopinathan Nakayama, Manabu Koseki, Haruhiko Zheng, Deyou Ezhkova, Elena PRC1 preserves epidermal tissue integrity independently of PRC2 |
title | PRC1 preserves epidermal tissue integrity independently of PRC2 |
title_full | PRC1 preserves epidermal tissue integrity independently of PRC2 |
title_fullStr | PRC1 preserves epidermal tissue integrity independently of PRC2 |
title_full_unstemmed | PRC1 preserves epidermal tissue integrity independently of PRC2 |
title_short | PRC1 preserves epidermal tissue integrity independently of PRC2 |
title_sort | prc1 preserves epidermal tissue integrity independently of prc2 |
topic | Research Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317312/ https://www.ncbi.nlm.nih.gov/pubmed/30567998 http://dx.doi.org/10.1101/gad.319939.118 |
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