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Evolving imprinting control regions: KRAB zinc fingers hold the key

The monoallelic parent of origin-specific expression of imprinted genes in mammals is regulated by differentially DNA methylated imprinting control regions (ICRs). In contrast to most of the genome, ICRs must maintain their DNA methylation and parental identity despite extensive epigenetic reprogram...

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Detalles Bibliográficos
Autores principales: Juan, Aimee M., Bartolomei, Marisa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317316/
https://www.ncbi.nlm.nih.gov/pubmed/30602436
http://dx.doi.org/10.1101/gad.322990.118