Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A

Repair of DNA double-strand breaks (DSBs) must be orchestrated properly within diverse chromatin domains in order to maintain genetic stability. Euchromatin and heterochromatin domains display major differences in histone modifications, biophysical properties, and spatiotemporal dynamics of DSB repa...

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Detalles Bibliográficos
Autores principales: Janssen, Aniek, Colmenares, Serafin U., Lee, Timothy, Karpen, Gary H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317320/
https://www.ncbi.nlm.nih.gov/pubmed/30578303
http://dx.doi.org/10.1101/gad.317537.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317320/
https://www.ncbi.nlm.nih.gov/pubmed/30578303
http://dx.doi.org/10.1101/gad.317537.118

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