Identifying Attributes That Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity Versus In Vivo DrugMatrix Transcriptomic Responses Across 130 Chemicals

Recent efforts aimed at integrating in vitro high-throughput screening (HTS) data into chemical toxicity assessments are necessitating increased understanding of concordance between chemical-induced responses observed in vitro versus in vivo. This investigation set out to (1) measure concordance bet...

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Detalles Bibliográficos
Autores principales: Klaren, William D, Ring, Caroline, Harris, Mark A, Thompson, Chad M, Borghoff, Susan, Sipes, Nisha S, Hsieh, Jui-Hua, Auerbach, Scott S, Rager, Julia E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Tox21 IN VITRO TO IN VIVO CONCORDANCE
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317427/
https://www.ncbi.nlm.nih.gov/pubmed/30202884
http://dx.doi.org/10.1093/toxsci/kfy220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317427/
https://www.ncbi.nlm.nih.gov/pubmed/30202884
http://dx.doi.org/10.1093/toxsci/kfy220

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