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6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations
Here we report on the synthesis, biophysical properties and molecular modeling of oligonucleotides containing unsaturated 6’-fluoro[4.3.0]bicyclo nucleotides (6’F-bc(4,3)-DNA). Two 6’F-bc(4,3) phosphoramidite building blocks (T and C) were synthesized starting from a previously described [3.3.0]bicy...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317435/ https://www.ncbi.nlm.nih.gov/pubmed/30643586 http://dx.doi.org/10.3762/bjoc.14.288 |