RNase H1 directs origin-specific initiation of DNA replication in human mitochondria

Human mitochondrial DNA (mtDNA) replication is first initiated at the origin of H-strand replication. The initiation depends on RNA primers generated by transcription from an upstream promoter (LSP). Here we reconstitute this process in vitro using purified transcription and replication factors. The...

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Detalles Bibliográficos
Autores principales: Posse, Viktor, Al-Behadili, Ali, Uhler, Jay P., Clausen, Anders R., Reyes, Aurelio, Zeviani, Massimo, Falkenberg, Maria, Gustafsson, Claes M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317783/
https://www.ncbi.nlm.nih.gov/pubmed/30605451
http://dx.doi.org/10.1371/journal.pgen.1007781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317783/
https://www.ncbi.nlm.nih.gov/pubmed/30605451
http://dx.doi.org/10.1371/journal.pgen.1007781

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