Cargando…

RNase H1 directs origin-specific initiation of DNA replication in human mitochondria

Human mitochondrial DNA (mtDNA) replication is first initiated at the origin of H-strand replication. The initiation depends on RNA primers generated by transcription from an upstream promoter (LSP). Here we reconstitute this process in vitro using purified transcription and replication factors. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Posse, Viktor, Al-Behadili, Ali, Uhler, Jay P., Clausen, Anders R., Reyes, Aurelio, Zeviani, Massimo, Falkenberg, Maria, Gustafsson, Claes M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317783/ https://www.ncbi.nlm.nih.gov/pubmed/30605451 http://dx.doi.org/10.1371/journal.pgen.1007781

Ejemplares similares

A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL
por: Al-Behadili, Ali, et al.
Publicado: (2018)

Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion
por: Misic, Jelena, et al.
Publicado: (2022)

Mitochondrial transcription termination factor 1 directs polar replication fork pausing
por: Shi, Yonghong, et al.
Publicado: (2016)

RNase H1 Regulates Mitochondrial Transcription and Translation via the Degradation of 7S RNA
por: Reyes, Aurelio, et al.
Publicado: (2020)

MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication
por: Uhler, Jay P., et al.
Publicado: (2016)

Ribonucleotides embedded in template DNA impair mitochondrial RNA polymerase progression
por: Singh, Meenakshi, et al.
Publicado: (2022)

TEFM is a potent stimulator of mitochondrial transcription elongation in vitro
por: Posse, Viktor, et al.
Publicado: (2015)

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication
por: Macao, Bertil, et al.
Publicado: (2015)

Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element
por: Jemt, Elisabeth, et al.
Publicado: (2015)

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop
por: Wanrooij, Paulina H., et al.
Publicado: (2012)

The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation
por: Posse, Viktor, et al.
Publicado: (2014)

TEFM regulates both transcription elongation and RNA processing in mitochondria
por: Jiang, Shan, et al.
Publicado: (2019)

POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA
por: Kühl, Inge, et al.
Publicado: (2016)

PCNA directs type 2 RNase H activity on DNA replication and repair substrates
por: Bubeck, Doryen, et al.
Publicado: (2011)

Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions
por: Persson, Örjan, et al.
Publicado: (2019)

The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis
por: Jemt, Elisabeth, et al.
Publicado: (2011)

Organization of DNA in Mammalian Mitochondria
por: Farge, Géraldine, et al.
Publicado: (2019)

RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases
por: Reyes, Aurelio, et al.
Publicado: (2020)

In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication
por: Miralles Fusté, Javier, et al.
Publicado: (2014)

Soybean antiviral immunity conferred by dsRNase targets the viral replication complex
por: Ishibashi, Kazuhiro, et al.
Publicado: (2019)

Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L
por: Park, Il-Hyun, et al.
Publicado: (2014)

RNase J1 and J2 Are Host-Encoded Factors for Plasmid Replication
por: Guimarães, Vanessa Andrade, et al.
Publicado: (2021)

Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA
por: Berglund, Anna-Karin, et al.
Publicado: (2017)

Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing
por: Basu, Swaraj, et al.
Publicado: (2020)

DNA stretching by bacterial initiators promotes replication origin melting
por: Duderstadt, Karl E., et al.
Publicado: (2011)

Origin-dependent initiation of DNA replication within telomeric sequences
por: Kurth, Isabel, et al.
Publicado: (2010)

IFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer
por: Yin, Huijing, et al.
Publicado: (2019)

Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria
por: Nicholls, Thomas J., et al.
Publicado: (2019)

The Origin and Evolution of RNase T2 Family and Gametophytic Self-incompatibility System in Plants
por: Lv, Shouzheng, et al.
Publicado: (2022)

Rapid turnover of DnaA at replication origin regions contributes to initiation control of DNA replication
por: Schenk, Katrin, et al.
Publicado: (2017)

Engineered RNase P Ribozymes Effectively Inhibit Human Cytomegalovirus Gene Expression and Replication
por: Yang, Zhu, et al.
Publicado: (2014)

Effective Inhibition of Human Immunodeficiency Virus 1 Replication by Engineered RNase P Ribozyme
por: Zeng, Wenbo, et al.
Publicado: (2012)

STUDIES ON THE ORIGIN OF YEAST MITOCHONDRIA
por: Linnane, Anthony W., et al.
Publicado: (1962)

The origin and early evolution of mitochondria
por: Gray, Michael W, et al.
Publicado: (2001)

Replication fork rescue in mammalian mitochondria
por: Torregrosa-Muñumer, Rubén, et al.
Publicado: (2019)

AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts
por: Sanchez-Alvarez, Miguel, et al.
Publicado: (2017)

Transcription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells
por: Sequeira-Mendes, Joana, et al.
Publicado: (2009)

Mutations in TIMM50 compromise cell survival in OxPhos‐dependent metabolic conditions
por: Reyes, Aurelio, et al.
Publicado: (2018)

Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability
por: Utani, Koichi, et al.
Publicado: (2017)

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA
por: Bailey, Laura J., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_bsvuovu124q33ap6jliou45076