AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance

The human 1q21.1 deletion of ten genes is associated with increased risk of schizophrenia. This deletion involves the β-subunit of the AMP-activated protein kinase (AMPK) complex, a key energy sensor in the cell. Although neurons have a high demand for energy and low capacity to store nutrients, the...

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Detalles Bibliográficos
Autores principales: Nagy, Stanislav, Maurer, Gianna W., Hentze, Julie L., Rose, Morten, Werge, Thomas M., Rewitz, Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317821/
https://www.ncbi.nlm.nih.gov/pubmed/30566533
http://dx.doi.org/10.1371/journal.pgen.1007623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317821/
https://www.ncbi.nlm.nih.gov/pubmed/30566533
http://dx.doi.org/10.1371/journal.pgen.1007623

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