Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations

Studies in experimental systems have identified a multitude of mutational mechanisms including DNA replication infidelity and DNA damage followed by inefficient repair or replicative bypass. However, the relative contributions of these mechanisms to human germline mutation remain unknown. Here, we s...

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Detalles Bibliográficos
Autores principales: Seplyarskiy, Vladimir B., Akkuratov, Evgeny E., Akkuratova, Natalia, Andrianova, Maria A., Nikolaev, Sergey I., Bazykin, Georgii A., Adameyko, Igor, Sunyaev, Shamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317876/
https://www.ncbi.nlm.nih.gov/pubmed/30510240
http://dx.doi.org/10.1038/s41588-018-0285-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317876/
https://www.ncbi.nlm.nih.gov/pubmed/30510240
http://dx.doi.org/10.1038/s41588-018-0285-7

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