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Xrs2 and Tel1 Independently Contribute to MR-Mediated DNA Tethering and Replisome Stability
The yeast Mre11-Rad50-Xrs2 (MRX) complex has structural, signaling, and catalytic functions in the response to DNA damage. Xrs2, the eukaryotic-specific component of the complex, is required for nuclear import of Mre11 and Rad50 and to recruit the Tel1 kinase to damage sites. We show that nuclear-lo...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317890/ https://www.ncbi.nlm.nih.gov/pubmed/30428339 http://dx.doi.org/10.1016/j.celrep.2018.10.030 |