Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

Pancreatic β cell physiology changes substantially throughout life, yet the mechanisms that drive these changes are poorly understood. Here, we performed comprehensive in vivo quantitative proteomic profiling of pancreatic islets from juvenile and 1-year-old mice. The analysis revealed striking diff...

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Detalles Bibliográficos
Autores principales: Wortham, Matthew, Benthuysen, Jacqueline R., Wallace, Martina, Savas, Jeffrey N., Mulas, Francesca, Divakaruni, Ajit S., Liu, Fenfen, Albert, Verena, Taylor, Brandon L., Sui, Yinghui, Saez, Enrique, Murphy, Anne N., Yates, John R., Metallo, Christian M., Sander, Maike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317899/
https://www.ncbi.nlm.nih.gov/pubmed/30517875
http://dx.doi.org/10.1016/j.celrep.2018.11.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317899/
https://www.ncbi.nlm.nih.gov/pubmed/30517875
http://dx.doi.org/10.1016/j.celrep.2018.11.031

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