Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning

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The bile acid activated transcription factor farnesoid X receptor (FXR) has revealed therapeutic potential as a molecular drug target for the treatment of hepatic and metabolic disorders. Despite strong efforts in FXR ligand development, the structural diversity among the known FXR modulators is lim...

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Detalles Bibliográficos
Autores principales: Merk, Daniel, Grisoni, Francesca, Schaller, Kay, Friedrich, Lukas, Schneider, Gisbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317935/
https://www.ncbi.nlm.nih.gov/pubmed/30622878
http://dx.doi.org/10.1002/open.201800156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317935/
https://www.ncbi.nlm.nih.gov/pubmed/30622878
http://dx.doi.org/10.1002/open.201800156

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