Induction of store operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Glioblastomas (GBM) are the most aggressive brain cancers without effective therapeutics. The Hippo pathway transcriptional coactivators YAP/TAZ were implicated as drivers in GBM progression and could be therapeutic targets. Here, we found in an unbiased screen of 1650 compounds that amlodipine is a...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Zhijun, Wei, Yiju, Zhang, Lei, Yee, Patricia P., Johnson, Martin, Zhang, Xuexin, Gulley, Melissa, Xavier, Jennifer, Trebak, Mohamed, Wang, Hong-Gang, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318057/
https://www.ncbi.nlm.nih.gov/pubmed/30082911
http://dx.doi.org/10.1038/s41388-018-0425-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318057/
https://www.ncbi.nlm.nih.gov/pubmed/30082911
http://dx.doi.org/10.1038/s41388-018-0425-7

Ejemplares similares