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Induction of store operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Glioblastomas (GBM) are the most aggressive brain cancers without effective therapeutics. The Hippo pathway transcriptional coactivators YAP/TAZ were implicated as drivers in GBM progression and could be therapeutic targets. Here, we found in an unbiased screen of 1650 compounds that amlodipine is a...

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Detalles Bibliográficos
Autores principales:	Liu, Zhijun, Wei, Yiju, Zhang, Lei, Yee, Patricia P., Johnson, Martin, Zhang, Xuexin, Gulley, Melissa, Xavier, Jennifer, Trebak, Mohamed, Wang, Hong-Gang, Li, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318057/ https://www.ncbi.nlm.nih.gov/pubmed/30082911 http://dx.doi.org/10.1038/s41388-018-0425-7

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