Cargando…

Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition

The NLRP3 inflammasome is unique among pattern recognition receptors in using changes in cellular physiology as a mechanism for sensing host danger. To dissect the physiological network controlling inflammasome activation, we screened for small-molecule activators and suppressors of IL-1β release in...

Descripción completa

Detalles Bibliográficos
Autores principales: Thi Tran, Uyen, Kitami, Toshimori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318214/
https://www.ncbi.nlm.nih.gov/pubmed/30740538
http://dx.doi.org/10.1038/s42003-018-0244-y