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Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition
The NLRP3 inflammasome is unique among pattern recognition receptors in using changes in cellular physiology as a mechanism for sensing host danger. To dissect the physiological network controlling inflammasome activation, we screened for small-molecule activators and suppressors of IL-1β release in...
| Главные авторы: | , |
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| Формат: | Online Статья Текст |
| Язык: | English |
| Опубликовано: |
Nature Publishing Group UK
2019
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| Предметы: | |
| Online-ссылка: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318214/ https://www.ncbi.nlm.nih.gov/pubmed/30740538 http://dx.doi.org/10.1038/s42003-018-0244-y |