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Quantitative Evaluation of Native Protein Folds and Assemblies by Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS)

Hydrogen deuterium exchange mass spectrometry (HDX-MS) has significant potential for protein structure initiatives but its relationship with protein conformations is unclear. We report on the efficacy of HDX-MS to distinguish between native and non-native proteins using a popular approach to calcula...

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Detalles Bibliográficos
Autores principales: Harris, Matthew J., Raghavan, Deepika, Borysik, Antoni J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318237/
https://www.ncbi.nlm.nih.gov/pubmed/30280315
http://dx.doi.org/10.1007/s13361-018-2070-3