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DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor

The NF-κB transcription factors are known to be extensively phosphorylated, with dynamic site-specific modification regulating their ability to dimerize and interact with DNA. p50, the proteolytic product of p105 (NF-κB1), forms homodimers that bind DNA but lack intrinsic transactivation function, f...

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Detalles Bibliográficos
Autores principales: Vonderach, Matthias, Byrne, Dominic P., Barran, Perdita E., Eyers, Patrick A., Eyers, Claire E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318249/
https://www.ncbi.nlm.nih.gov/pubmed/29873020
http://dx.doi.org/10.1007/s13361-018-1984-0