Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Diverse entry inhibitors targeting the gp120 subunit of the HIV-1 envelope (Env) trimer have been developed including BMS-626529, also called temsavir, a prodrug version of which is currently in phase III clinical trials. Here we report the characterization of a panel of small-molecule inhibitors in...

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Detalles Bibliográficos
Autores principales: Lai, Yen-Ting, Wang, Tao, O’Dell, Sijy, Louder, Mark K., Schön, Arne, Cheung, Crystal S. F., Chuang, Gwo-Yu, Druz, Aliaksandr, Lin, Bob, McKee, Krisha, Peng, Dongjun, Yang, Yongping, Zhang, Baoshan, Herschhorn, Alon, Sodroski, Joseph, Bailer, Robert T., Doria-Rose, Nicole A., Mascola, John R., Langley, David R., Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318274/
https://www.ncbi.nlm.nih.gov/pubmed/30604750
http://dx.doi.org/10.1038/s41467-018-07851-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318274/
https://www.ncbi.nlm.nih.gov/pubmed/30604750
http://dx.doi.org/10.1038/s41467-018-07851-1

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