CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

CRISPR/Cas9 guided gene-editing is a potential therapeutic tool, however application to neurodegenerative disease models has been limited. Moreover, conventional mutation correction by gene-editing would only be relevant for the small fraction of neurodegenerative cases that are inherited. Here we i...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Jichao, Carlson-Stevermer, Jared, Das, Utpal, Shen, Minjie, Delenclos, Marion, Snead, Amanda M., Koo, So Yeon, Wang, Lina, Qiao, Dianhua, Loi, Jonathan, Petersen, Andrew J., Stockton, Michael, Bhattacharyya, Anita, Jones, Mathew V., Zhao, Xinyu, McLean, Pamela J., Sproul, Andrew A., Saha, Krishanu, Roy, Subhojit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318289/
https://www.ncbi.nlm.nih.gov/pubmed/30604771
http://dx.doi.org/10.1038/s41467-018-07971-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318289/
https://www.ncbi.nlm.nih.gov/pubmed/30604771
http://dx.doi.org/10.1038/s41467-018-07971-8

Ejemplares similares