Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

Neurokinins (or tachykinins) are peptides that modulate a wide variety of human physiology through the neurokinin G protein-coupled receptor family, implicated in a diverse array of pathological processes. Here we report high-resolution crystal structures of the human NK(1) receptor (NK(1)R) bound t...

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Detalles Bibliográficos
Autores principales: Schöppe, Jendrik, Ehrenmann, Janosch, Klenk, Christoph, Rucktooa, Prakash, Schütz, Marco, Doré, Andrew S., Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318301/
https://www.ncbi.nlm.nih.gov/pubmed/30604743
http://dx.doi.org/10.1038/s41467-018-07939-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318301/
https://www.ncbi.nlm.nih.gov/pubmed/30604743
http://dx.doi.org/10.1038/s41467-018-07939-8

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