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Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
Neurokinins (or tachykinins) are peptides that modulate a wide variety of human physiology through the neurokinin G protein-coupled receptor family, implicated in a diverse array of pathological processes. Here we report high-resolution crystal structures of the human NK(1) receptor (NK(1)R) bound t...
Autores principales: | Schöppe, Jendrik, Ehrenmann, Janosch, Klenk, Christoph, Rucktooa, Prakash, Schütz, Marco, Doré, Andrew S., Plückthun, Andreas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318301/ https://www.ncbi.nlm.nih.gov/pubmed/30604743 http://dx.doi.org/10.1038/s41467-018-07939-8 |
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