Bioenergetic modulation with the mitochondria uncouplers SR4 and niclosamide prevents proliferation and growth of treatment-naïve and vemurafenib-resistant melanomas

BRAF mutations are detected in >50% of all melanomas. These mutations impair the LKB1-AMPK signaling, an important metabolic pathway associated with cell growth, proliferation and survival. Melanoma patients with BRAF mutations are usually treated with BRAF inhibitors such as vemurafenib, but res...

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Detalles Bibliográficos
Autores principales: Figarola, James L., Singhal, Jyotsana, Singhal, Sharad, Kusari, Jyotirmoy, Riggs, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319337/
https://www.ncbi.nlm.nih.gov/pubmed/30651927
http://dx.doi.org/10.18632/oncotarget.26421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319337/
https://www.ncbi.nlm.nih.gov/pubmed/30651927
http://dx.doi.org/10.18632/oncotarget.26421

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