Bioenergetic modulation with the mitochondria uncouplers SR4 and niclosamide prevents proliferation and growth of treatment-naïve and vemurafenib-resistant melanomas

BRAF mutations are detected in >50% of all melanomas. These mutations impair the LKB1-AMPK signaling, an important metabolic pathway associated with cell growth, proliferation and survival. Melanoma patients with BRAF mutations are usually treated with BRAF inhibitors such as vemurafenib, but res...

Descripción completa

Detalles Bibliográficos
Autores principales: Figarola, James L., Singhal, Jyotsana, Singhal, Sharad, Kusari, Jyotirmoy, Riggs, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319337/
https://www.ncbi.nlm.nih.gov/pubmed/30651927
http://dx.doi.org/10.18632/oncotarget.26421

Ejemplares similares

Ejemplares similares