Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma

PURPOSE: The purpose was to determine the safety and antitumor activity of a folate-tubulysin conjugate (EC0531) in a relevant preclinical animal model, dogs with naturally-occurring invasive urothelial carcinoma (iUC). Canine iUC is an aggressive cancer with high folate receptor (FR) expression sim...

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Detalles Bibliográficos
Autores principales: Szigetvari, Nicholas M., Dhawan, Deepika, Ramos-Vara, José A., Leamon, Christopher P., Klein, Patrick J., Ruple, A. Audrey, Heng, Hock Gan, Pugh, Michael R., Rao, Satish, Vlahov, Iontcho R., Deshuillers, Pierre L., Low, Philip S., Fourez, Lindsey M., Cournoyer, Ashleigh M., Knapp, Deborah W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319348/
https://www.ncbi.nlm.nih.gov/pubmed/30651934
http://dx.doi.org/10.18632/oncotarget.26455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319348/
https://www.ncbi.nlm.nih.gov/pubmed/30651934
http://dx.doi.org/10.18632/oncotarget.26455

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