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Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway

AIM: To investigate the effects of catalpol on muscular atrophy induced by sciatic nerve crush injury (SNCI). METHODS: Seventy male Kunming mice were randomized into five groups (n=10): model, sham, catalpol (Cat), rapamycin (Rapa), and catalpol+rapamycin (Rapa+Cat). The ratio of gastrocnemius muscl...

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Detalles Bibliográficos
Autores principales:	Wang, Yuan, Shao, Yali, Gao, Yuqing, Wan, Guoran, Wan, Dong, Zhu, Huifeng, Qiu, Yan, Ye, Xiyue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319426/ https://www.ncbi.nlm.nih.gov/pubmed/30643390 http://dx.doi.org/10.2147/DDDT.S188968

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