Transglutaminase 2 Promotes Autophagy by LC3 Induction through p53 Depletion in Cancer Cell

Transglutaminase 2 (TGase 2) plays a key role in p53 regulation, depleting p53 tumor suppressor through autophagy in renal cell carcinoma. We found that microtubule-associated protein 1A/1B-light chain 3 (LC3), a hallmark of autophagy, were tightly associated with the level of TGase 2 in cancer cell...

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Detalles Bibliográficos
Autores principales: Kang, Joon Hee, Lee, Seon-Hyeong, Cheong, Heesun, Lee, Chang Hoon, Kim, Soo-Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319544/
https://www.ncbi.nlm.nih.gov/pubmed/30231606
http://dx.doi.org/10.4062/biomolther.2018.140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319544/
https://www.ncbi.nlm.nih.gov/pubmed/30231606
http://dx.doi.org/10.4062/biomolther.2018.140

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