Cargando…

Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)(1A) receptor, may possess analgesic and anxiolytic effects. However, its effects on 5-HT neuronal activity, as well as its impact on models of neuropathic pain ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Gregorio, Danilo, McLaughlin, Ryan J., Posa, Luca, Ochoa-Sanchez, Rafael, Enns, Justine, Lopez-Canul, Martha, Aboud, Matthew, Maione, Sabatino, Comai, Stefano, Gobbi, Gabriella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597/ https://www.ncbi.nlm.nih.gov/pubmed/30157131 http://dx.doi.org/10.1097/j.pain.0000000000001386

Ejemplares similares

PM361. The hallucinogen D-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT(1A), D(2) and TAAR(1) receptors
por: Gregorio, Danilo De, et al.
Publicado: (2016)

PT628. First in class melatonin MT2 receptors agonists for neuropathic pain
por: Gobbi, Gabriella, et al.
Publicado: (2016)

Melatonin MT(1) and MT(2) Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle
por: López-Canul, Martha, et al.
Publicado: (2019)

Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats
por: Lee, Ji-Hye, et al.
Publicado: (2014)

Oral Cannabidiol Prevents Allodynia and Neurological Dysfunctions in a Mouse Model of Mild Traumatic Brain Injury
por: Belardo, Carmela, et al.
Publicado: (2019)

Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission
por: De Gregorio, Danilo, et al.
Publicado: (2021)

d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology
por: De Gregorio, Danilo, et al.
Publicado: (2016)

Lysergic acid diethylamide differentially modulates the reticular thalamus, mediodorsal thalamus, and infralimbic prefrontal cortex: An in vivo electrophysiology study in male mice
por: Inserra, Antonio, et al.
Publicado: (2021)

Effects of Chronic Exposure to Low-Dose delta-9-Tetrahydrocannabinol in Adolescence and Adulthood on Serotonin/Norepinephrine Neurotransmission and Emotional Behavior
por: De Gregorio, Danilo, et al.
Publicado: (2020)

Evaluating the Potential Use of Serotonergic Psychedelics in Autism Spectrum Disorder
por: Markopoulos, Athanasios, et al.
Publicado: (2022)

Imbalance in the spinal serotonergic pathway induces aggravation of mechanical allodynia and microglial activation in carrageenan inflammation
por: Jin, Junxiu, et al.
Publicado: (2023)

Involvement of Serotonergic System in Oxaliplatin-Induced Neuropathic Pain
por: Lee, Ji Hwan, et al.
Publicado: (2021)

[6]-Shogaol Attenuates Oxaliplatin-Induced Allodynia through Serotonergic Receptors and GABA in the Spinal Cord in Mice
por: Kim, Suyong, et al.
Publicado: (2022)

Role of Neurotrophins in Neuropathic Pain
por: Siniscalco, Dario, et al.
Publicado: (2011)

Pentoxifylline decreases allodynia and hyperalgesia in a rat model of neuropathic pain
por: Vakili, A., et al.
Publicado: (2011)

Silent cold-sensing neurons contribute to cold allodynia in neuropathic pain
por: MacDonald, Donald Iain, et al.
Publicado: (2021)

SKF96365 impedes spinal glutamatergic transmission-mediated neuropathic allodynia
por: Wang, Qiru, et al.
Publicado: (2023)

Potential of Cannabidiol for the Treatment of Viral Hepatitis
por: Lowe, Henry I. C., et al.
Publicado: (2017)

The Contribution of TRPM8 and TRPA1 Channels to Cold Allodynia and Neuropathic Pain
por: Caspani, Ombretta, et al.
Publicado: (2009)

Intact cutaneous C fibre afferent properties in mechanical and cold neuropathic allodynia
por: Hulse, Richard, et al.
Publicado: (2010)

Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats
por: Yoon, Jeong-Ho, et al.
Publicado: (2018)

Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain
por: Zhou, Ya-qun, et al.
Publicado: (2020)

The Adrenal Medulla Modulates Mechanical Allodynia in a Rat Model of Neuropathic Pain
por: Arribas-Blázquez, Marina, et al.
Publicado: (2020)

Brain Functional Alteration at Different Stages of Neuropathic Pain With Allodynia and Emotional Disorders
por: Zhang, Ya-Nan, et al.
Publicado: (2022)

Microglia and p38 MAPK Inhibitors Suppress Development of Mechanical Allodynia in Both Sexes in a Mouse Model of Antiretroviral-Induced Neuropathic Pain
por: Alhadlaq, Maryam W., et al.
Publicado: (2023)

Functional characterization of cannabidiol effect on the serotonergic neurons of the dorsal raphe nucleus in rat brain slices
por: Mendiguren, Aitziber, et al.
Publicado: (2022)

Behavioral, Biochemical and Electrophysiological Changes in Spared Nerve Injury Model of Neuropathic Pain
por: Guida, Francesca, et al.
Publicado: (2020)

Alleviating neuropathic pain mechanical allodynia by increasing Cdh1 in the anterior cingulate cortex
por: Tan, Wei, et al.
Publicado: (2015)

A comparison of early and late treatments on allodynia and its chronification in experimental neuropathic pain
por: Salvat, Eric, et al.
Publicado: (2017)

Effect of autophagy on allodynia, hyperalgesia and astrocyte activation in a rat model of neuropathic pain
por: Chen, Hongguang, et al.
Publicado: (2018)

Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model
por: Son, Dang Bao, et al.
Publicado: (2021)

Methods for Evaluating Sensory, Affective and Cognitive Disorders in Neuropathic Rodents
por: Palazzo, Enza, et al.
Publicado: (2021)

Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection
por: Guida, Francesca, et al.
Publicado: (2012)

The GlyT1 Inhibitor Bitopertin Ameliorates Allodynia and Hyperalgesia in Animal Models of Neuropathic and Inflammatory Pain
por: Armbruster, Anja, et al.
Publicado: (2018)

Upregulation of Glutamate Transporter 1 by Clavulanic Acid Administration and Attenuation of Allodynia and Hyperalgesia in Neuropathic Rats
por: Amin, Bahareh, et al.
Publicado: (2019)

Evidence For Cannabidiol Modulation of Serotonergic Transmission in a Model of Osteoarthritis via in vivo PET Imaging and Behavioral Assessment
por: Ding, Yu-Shin, et al.
Publicado: (2022)

Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
por: Aby, Franck, et al.
Publicado: (2022)

Spinal Astrocytic Activation Contributes to Mechanical Allodynia in a Rat Chemotherapy-Induced Neuropathic Pain Model
por: Ji, Xi-Tuan, et al.
Publicado: (2013)

Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms
por: Aman, Urooj, et al.
Publicado: (2016)

Epidural Sustained Release Ropivacaine Prolongs Anti-Allodynia and Anti-Hyperalgesia in Developing and Established Neuropathic Pain
por: Li, Teng-Fei, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_291km56e9id45gs163m42a6dkc