Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease with the microtubule-binding protein tau, but the mechanism of action of LRRK2 mutations and the molecular connection between tau and Parkinso...

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Detalles Bibliográficos
Autores principales: Bardai, Farah H., Ordonez, Dalila G., Bailey, Rachel M., Hamm, Matthew, Lewis, Jada, Feany, Mel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319772/
https://www.ncbi.nlm.nih.gov/pubmed/30571694
http://dx.doi.org/10.1371/journal.pbio.2006265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319772/
https://www.ncbi.nlm.nih.gov/pubmed/30571694
http://dx.doi.org/10.1371/journal.pbio.2006265

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