Cargando…

Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine

Mutations in SPINT2 encoding the epithelial serine protease inhibitor hepatocyte growth factor activator inhibitor-2 (HAI-2) are associated with congenital tufting enteropathy. However, the functions of HAI-2 in vivo are poorly understood. Here we used tamoxifen-induced Cre-LoxP recombination in mic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kawaguchi, Makiko, Yamamoto, Koji, Takeda, Naoki, Fukushima, Tsuyoshi, Yamashita, Fumiki, Sato, Katsuaki, Kitamura, Kenichiro, Hippo, Yoshitaka, Janetka, James W., Kataoka, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320337/ https://www.ncbi.nlm.nih.gov/pubmed/30623107 http://dx.doi.org/10.1038/s42003-018-0255-8

Ejemplares similares

Insufficiency of hepatocyte growth factor activator inhibitor‐1 confers lymphatic invasion of tongue carcinoma cells
por: Izumi, Aya, et al.
Publicado: (2022)

Protease‐activated receptor‐2 accelerates intestinal tumor formation through activation of nuclear factor‐κB signaling and tumor angiogenesis in Apc (Min/+) mice
por: Kawaguchi, Makiko, et al.
Publicado: (2020)

Aberrant methylation and silencing of the SPINT2 gene in high‐grade gliomas
por: Fukushima, Tsuyoshi, et al.
Publicado: (2018)

Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model
por: Ye, Jingjia, et al.
Publicado: (2014)

Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/SPINT2 contributes to invasive growth of oral squamous cell carcinoma cells
por: Yamamoto, Koji, et al.
Publicado: (2018)

Prognostic significance of hepatocyte growth factor activator inhibitor type 1 (HAI-1) immunoreactivity in pancreatic ductal adenocarcinoma
por: Sakugawa, Chihiro, et al.
Publicado: (2017)

Mechanisms of Hepatocyte Growth Factor Activation in Cancer Tissues
por: Kawaguchi, Makiko, et al.
Publicado: (2014)

Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM
por: Szabo, Roman, et al.
Publicado: (2023)

Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the Apc(Min/+) model
por: Kawaguchi, Makiko, et al.
Publicado: (2016)

Adrenomedullin alleviates mucosal injury in experimental colitis and increases claudin‐4 expression in the colonic epithelium
por: Kawaguchi, Makiko, et al.
Publicado: (2023)

Hepatocyte Growth Factor Activator: A Proteinase Linking Tissue Injury with Repair
por: Fukushima, Tsuyoshi, et al.
Publicado: (2018)

Ghrelin administration suppresses inflammation-associated colorectal carcinogenesis in mice
por: Kawaguchi, Makiko, et al.
Publicado: (2015)

Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment
por: Owusu, Benjamin Yaw, et al.
Publicado: (2017)

The detection of EpCAM(+) and EpCAM(–) circulating tumor cells
por: Wit, Sanne de, et al.
Publicado: (2015)

EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier
por: Higashi, Tomohito, et al.
Publicado: (2022)

Multiple cardiac rhabdomyomas not associated with tuberous sclerosis in a dizygotic twins: a case report
por: Yamamoto, Koji, et al.
Publicado: (2021)

Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition
por: Maru, Yoshiaki, et al.
Publicado: (2021)

Expression of EpCAM(MF) and EpCAM(MT) variants in human carcinomas
por: Fong, Dominic, et al.
Publicado: (2014)

BMP9‐ID1 signaling promotes EpCAM‐positive cancer stem cell properties in hepatocellular carcinoma
por: Chen, Han, et al.
Publicado: (2021)

Current Status of Patient-Derived Ovarian Cancer Models
por: Maru, Yoshiaki, et al.
Publicado: (2019)

Twists and turns in Kras-driven tumor initiation
por: Maru, Yoshiaki, et al.
Publicado: (2021)

Two-Way Development of the Genetic Model for Endometrial Tumorigenesis in Mice: Current and Future Perspectives
por: Maru, Yoshiaki, et al.
Publicado: (2021)

Editorial: Development of in vitro toxicology methods using organoid systems and toxicogenomic approaches
por: Imai, Toshio, et al.
Publicado: (2022)

Hepatocytic parental progenitor cells of rat small hepatocytes maintain self-renewal capability after long-term culture
por: Ishii, Masayuki, et al.
Publicado: (2017)

Sporadic PCDH18 somatic mutations in EpCAM-positive hepatocellular carcinoma
por: Hayashi, Takehiro, et al.
Publicado: (2017)

Essential Palatal Tremor Managed by Cognitive Behavioral Therapy
por: Kitamura, Tomohisa, et al.
Publicado: (2015)

EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance
por: Jiang, Lingling, et al.
Publicado: (2016)

Establishment and characterization of patient‐derived organoids from a young patient with cervical clear cell carcinoma
por: Maru, Yoshiaki, et al.
Publicado: (2019)

Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration
por: Yano, Koichi, et al.
Publicado: (2022)

Corrigendum: EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance
por: Jiang, Lingling, et al.
Publicado: (2017)

Complete Loss of EPCAM Immunoexpression Identifies EPCAM Deletion Carriers in MSH2-Negative Colorectal Neoplasia
por: Cuatrecasas, Míriam, et al.
Publicado: (2020)

Recent Advances in Implantation-Based Genetic Modeling of Biliary Carcinogenesis in Mice
por: Izumiya, Masashi, et al.
Publicado: (2021)

A case of carcinoma ex pleomorphic adenoma arising from multinodular pleomorphic adenoma of the buccal region
por: Yamamoto, Koji, et al.
Publicado: (2019)

Expression of EpCAM in uveal melanoma
por: Odashiro, Danilo N, et al.
Publicado: (2006)

Biology and clinical relevance of EpCAM
por: Keller, Laura, et al.
Publicado: (2019)

EpCAM as Modulator of Tissue Plasticity
por: Fagotto, François
Publicado: (2020)

EpCAM(high) and EpCAM(low) circulating tumor cells in metastatic prostate and breast cancer patients
por: de Wit, Sanne, et al.
Publicado: (2018)

Author Correction: EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance
por: Jiang, Lingling, et al.
Publicado: (2020)

EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice
por: Lei, Zili, et al.
Publicado: (2022)

HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles
por: Lee, Deokcheol, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qkmpglebup6jcg8non33g60v43