Inhibitory Effect of Synthetic Flavone Derivatives on Pan-Aurora Kinases: Induction of G2/M Cell-Cycle Arrest and Apoptosis in HCT116 Human Colon Cancer Cells

Members of the aurora kinase family are Ser/Thr kinases involved in regulating mitosis. Multiple promising clinical trials to target aurora kinases are in development. To discover flavones showing growth inhibitory effects on cancer cells, 36 flavone derivatives were prepared, and their cytotoxicity...

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Detalles Bibliográficos
Autores principales: Shin, Soon Young, Lee, Youngshim, Kim, Beom Soo, Lee, Junho, Ahn, Seunghyun, Koh, Dongsoo, Lim, Yoongho, Lee, Young Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320900/
https://www.ncbi.nlm.nih.gov/pubmed/30562979
http://dx.doi.org/10.3390/ijms19124086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320900/
https://www.ncbi.nlm.nih.gov/pubmed/30562979
http://dx.doi.org/10.3390/ijms19124086

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