Factors Affecting Intracellular Delivery and Release of Hydrophilic Versus Hydrophobic Cargo from Mesoporous Silica Nanoparticles on 2D and 3D Cell Cultures

Intracellular drug delivery by mesoporous silica nanoparticles (MSNs) carrying hydrophilic and hydrophobic fluorophores as model drug cargo is demonstrated on 2D cellular and 3D tumor organoid level. Two different MSN designs, chosen on the basis of the characteristics of the loaded cargo, were used...

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Detalles Bibliográficos
Autores principales: Desai, Diti, Åkerfelt, Malin, Prabhakar, Neeraj, Toriseva, Mervi, Näreoja, Tuomas, Zhang, Jixi, Nees, Matthias, Rosenholm, Jessica M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320991/
https://www.ncbi.nlm.nih.gov/pubmed/30453596
http://dx.doi.org/10.3390/pharmaceutics10040237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320991/
https://www.ncbi.nlm.nih.gov/pubmed/30453596
http://dx.doi.org/10.3390/pharmaceutics10040237

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