Cargando…
Factors Affecting Intracellular Delivery and Release of Hydrophilic Versus Hydrophobic Cargo from Mesoporous Silica Nanoparticles on 2D and 3D Cell Cultures
Intracellular drug delivery by mesoporous silica nanoparticles (MSNs) carrying hydrophilic and hydrophobic fluorophores as model drug cargo is demonstrated on 2D cellular and 3D tumor organoid level. Two different MSN designs, chosen on the basis of the characteristics of the loaded cargo, were used...
Autores principales: | Desai, Diti, Åkerfelt, Malin, Prabhakar, Neeraj, Toriseva, Mervi, Näreoja, Tuomas, Zhang, Jixi, Nees, Matthias, Rosenholm, Jessica M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320991/ https://www.ncbi.nlm.nih.gov/pubmed/30453596 http://dx.doi.org/10.3390/pharmaceutics10040237 |
Ejemplares similares
-
Comparison of Polydopamine-Coated Mesoporous Silica Nanorods and Spheres for the Delivery of Hydrophilic and Hydrophobic Anticancer Drugs
por: Pada, Anna-Karin, et al.
Publicado: (2019) -
Stimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery
por: Prabhakar, Neeraj, et al.
Publicado: (2016) -
Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields
por: Robinson, Sean, et al.
Publicado: (2015) -
Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells
por: Liu, Qian, et al.
Publicado: (2012) -
A high-content image analysis approach for quantitative measurements of chemosensitivity in patient-derived tumor microtissues
por: Ahonen, Ilmari, et al.
Publicado: (2017)