A Pt(IV) Prodrug Combining Chlorambucil and Cisplatin: A Dual-Acting Weapon for Targeting DNA in Cancer Cells

In this study, two DNA-targeting agents, cisplatin and chlorambucil, were combined in a Pt(IV) prodrug, 1, which was thoroughly characterized by means of spectroscopic and spectrometric techniques. Tested towards a panel of various human tumor cell lines, this compound showed superior in vitro antit...

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Detalles Bibliográficos
Autores principales: Montagner, Diego, Tolan, Dina, Andriollo, Emma, Gandin, Valentina, Marzano, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321036/
https://www.ncbi.nlm.nih.gov/pubmed/30486477
http://dx.doi.org/10.3390/ijms19123775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321036/
https://www.ncbi.nlm.nih.gov/pubmed/30486477
http://dx.doi.org/10.3390/ijms19123775

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