Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells

We have designed and synthesized 6 ent-Kaurane-type diterpenoid derivatives containing α,β-unsaturated ketone moieties. In vitro, activity was evaluated against three human tumor cell lines and a rat myogenic cell line (HepG2, NSCLC-H292, SNU-1040, L6) by MTT assay. All the tested compounds exhibite...

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Detalles Bibliográficos
Autores principales: Hu, Yu, Li, Xiao-Nian, Ma, Ze-Jin, Puno, Pema-Tenzin, Zhao, Yong, Zhao, Yan, Xiao, Ye-Zhi, Zhang, Wei, Liu, Jing-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321055/
https://www.ncbi.nlm.nih.gov/pubmed/30563165
http://dx.doi.org/10.3390/molecules23123216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321055/
https://www.ncbi.nlm.nih.gov/pubmed/30563165
http://dx.doi.org/10.3390/molecules23123216

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