Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate

A convenient and effective route for the synthesis of aryl(difluoromethyl)phosphonates has been developed based on cross-coupling reactions. Upon treatment with a stoichiometric amount (or a catalytic amount in some cases) of CuI and CsF, aryl iodides reacted smoothly with (silyldifluoromethyl)phosp...

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Detalles Bibliográficos
Autores principales: Komoda, Kazuki, Iwamoto, Rei, Kasumi, Masakazu, Amii, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321065/
https://www.ncbi.nlm.nih.gov/pubmed/30545029
http://dx.doi.org/10.3390/molecules23123292
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author Komoda, Kazuki
Iwamoto, Rei
Kasumi, Masakazu
Amii, Hideki
author_facet Komoda, Kazuki
Iwamoto, Rei
Kasumi, Masakazu
Amii, Hideki
author_sort Komoda, Kazuki
collection PubMed
description A convenient and effective route for the synthesis of aryl(difluoromethyl)phosphonates has been developed based on cross-coupling reactions. Upon treatment with a stoichiometric amount (or a catalytic amount in some cases) of CuI and CsF, aryl iodides reacted smoothly with (silyldifluoromethyl)phosphonates to give the corresponding aryl(difluoromethyl)phosphonates in good yields.
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spelling pubmed-63210652019-01-14 Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate Komoda, Kazuki Iwamoto, Rei Kasumi, Masakazu Amii, Hideki Molecules Brief Report A convenient and effective route for the synthesis of aryl(difluoromethyl)phosphonates has been developed based on cross-coupling reactions. Upon treatment with a stoichiometric amount (or a catalytic amount in some cases) of CuI and CsF, aryl iodides reacted smoothly with (silyldifluoromethyl)phosphonates to give the corresponding aryl(difluoromethyl)phosphonates in good yields. MDPI 2018-12-11 /pmc/articles/PMC6321065/ /pubmed/30545029 http://dx.doi.org/10.3390/molecules23123292 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Komoda, Kazuki
Iwamoto, Rei
Kasumi, Masakazu
Amii, Hideki
Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate
title Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate
title_full Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate
title_fullStr Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate
title_full_unstemmed Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate
title_short Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate
title_sort copper-promoted cross-coupling reactions for the synthesis of aryl(difluoromethyl)phosphonates using trimethylsilyl(difluoromethyl)phosphonate
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321065/
https://www.ncbi.nlm.nih.gov/pubmed/30545029
http://dx.doi.org/10.3390/molecules23123292
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