Analysis of Vipadenant and Its In Vitro and In Vivo Metabolites via Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry

A simple and sensitive liquid chromatography–quadrupole-time-of-flight–mass spectrometric (LC-QTOF-MS) assay has been developed for the evaluation of drug metabolism and pharmacokinetics (PK) properties of vipadenant in rat, a selective A2a receptor antagonist as one of the novel immune checkpoint i...

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Detalles Bibliográficos
Autores principales: Shin, Seok-Ho, Park, Min-Ho, Byeon, Jin-Ju, Lee, Byeong ill, Park, Yuri, Kim, Nahye, Choi, Jangmi, Shin, Young G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321172/
https://www.ncbi.nlm.nih.gov/pubmed/30513962
http://dx.doi.org/10.3390/pharmaceutics10040260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321172/
https://www.ncbi.nlm.nih.gov/pubmed/30513962
http://dx.doi.org/10.3390/pharmaceutics10040260

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