From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development

The zebrafish (Danio rerio) embryo is currently explored as an alternative for developmental toxicity testing. As maternal metabolism is lacking in this model, knowledge of the disposition of xenobiotics during zebrafish organogenesis is pivotal in order to correctly interpret the outcome of teratog...

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Detalles Bibliográficos
Autores principales: Verbueken, Evy, Bars, Chloé, Ball, Jonathan S., Periz-Stanacev, Jelena, Marei, Waleed F. A., Tochwin, Anna, Gabriëls, Isabelle J., Michiels, Ellen D. G., Stinckens, Evelyn, Vergauwen, Lucia, Knapen, Dries, Van Ginneken, Chris J., Van Cruchten, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321216/
https://www.ncbi.nlm.nih.gov/pubmed/30544719
http://dx.doi.org/10.3390/ijms19123976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321216/
https://www.ncbi.nlm.nih.gov/pubmed/30544719
http://dx.doi.org/10.3390/ijms19123976

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