Cargando…

From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development

The zebrafish (Danio rerio) embryo is currently explored as an alternative for developmental toxicity testing. As maternal metabolism is lacking in this model, knowledge of the disposition of xenobiotics during zebrafish organogenesis is pivotal in order to correctly interpret the outcome of teratog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Verbueken, Evy, Bars, Chloé, Ball, Jonathan S., Periz-Stanacev, Jelena, Marei, Waleed F. A., Tochwin, Anna, Gabriëls, Isabelle J., Michiels, Ellen D. G., Stinckens, Evelyn, Vergauwen, Lucia, Knapen, Dries, Van Ginneken, Chris J., Van Cruchten, Steven J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321216/ https://www.ncbi.nlm.nih.gov/pubmed/30544719 http://dx.doi.org/10.3390/ijms19123976

Ejemplares similares

In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development
por: Verbueken, Evy, et al.
Publicado: (2017)

UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
por: Saad, Moayad, et al.
Publicado: (2017)

Developmental Toxicity and Biotransformation of Two Anti-Epileptics in Zebrafish Embryos and Early Larvae
por: Bars, Chloé, et al.
Publicado: (2021)

Evaluating Complex Mixtures in the Zebrafish Embryo by Reconstituting Field Water Samples: A Metal Pollution Case Study
por: Michiels, Ellen D. G., et al.
Publicado: (2017)

Mass Spectrometry-Based Zebrafish Toxicometabolomics: A Review of Analytical and Data Quality Challenges
por: da Silva, Katyeny Manuela, et al.
Publicado: (2021)

In Vitro Investigation of Six Antioxidants for Pig Diets
por: Vergauwen, Hans, et al.
Publicado: (2016)

Optimizing the Use of Zebrafish Feeding Trials for the Safety Evaluation of Genetically Modified Crops
por: Gabriëls, Isabelle J., et al.
Publicado: (2019)

Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets
por: Vergauwen, Hans, et al.
Publicado: (2017)

DMSO Concentrations up to 1% are Safe to be Used in the Zebrafish Embryo Developmental Toxicity Assay
por: Hoyberghs, Jente, et al.
Publicado: (2021)

Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny
por: Valenzuela, Allan, et al.
Publicado: (2023)

Thyroid Hormone Disruptors Interfere with Molecular Pathways of Eye Development and Function in Zebrafish
por: Baumann, Lisa, et al.
Publicado: (2019)

Refinement of the zebrafish embryo developmental toxicity assay
por: Hoyberghs, Jente, et al.
Publicado: (2020)

Changes of the glutathione redox system during the weaning transition in piglets, in relation to small intestinal morphology and barrier function
por: Degroote, Jeroen, et al.
Publicado: (2020)

The Effect of Dietary Quercetin on the Glutathione Redox System and Small Intestinal Functionality of Weaned Piglets
por: Degroote, Jeroen, et al.
Publicado: (2019)

Whole-genome microarray analysis and functional characterization reveal distinct gene expression profiles and patterns in two mouse models of ileal inflammation
por: Avula, Leela Rani, et al.
Publicado: (2012)

A Medium-Throughput System for In Vitro Oxidative Stress Assessment in IPEC-J2 Cells
por: Ayuso, Miriam, et al.
Publicado: (2020)

Transcriptional Analysis of The Adaptive Digestive System of The Migratory Locust in Response to Plant Defensive Protease Inhibitors
por: Spit, Jornt, et al.
Publicado: (2016)

Trolox and Ascorbic Acid Reduce Direct and Indirect Oxidative Stress in the IPEC-J2 Cells, an In Vitro Model for the Porcine Gastrointestinal Tract
por: Vergauwen, Hans, et al.
Publicado: (2015)

Handling Associated with Drenching Does Not Impact Survival and General Health of Low Birth Weight Piglets
por: Van Tichelen, Kevin, et al.
Publicado: (2021)

Drenching Bovine Colostrum, Quercetin or Fructo-Oligosaccharides Has No Effect on Health or Survival of Low Birth Weight Piglets
por: Van Tichelen, Kevin, et al.
Publicado: (2021)

Ontogeny of CYP3A and UGT activity in preterm piglets: a translational model for drug metabolism in preterm newborns
por: Buyssens, Laura, et al.
Publicado: (2023)

Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model
por: Fan, Xiaoyu, et al.
Publicado: (2020)

The Effect of Drenching (Very) Low Birth Weight Piglets with a Dense, Concentrated Milk Replacer at Farms with Differing Farrowing Management
por: Van Tichelen, Kevin, et al.
Publicado: (2022)

Biotransformation of Deoxynivalenol by a Dual-Member Bacterial Consortium Isolated from Tenebrio molitor Larval Feces
por: Wang, Yang, et al.
Publicado: (2023)

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project
por: Braeuning, Albert, et al.
Publicado: (2023)

Deiodinase Knockdown during Early Zebrafish Development Affects Growth, Development, Energy Metabolism, Motility and Phototransduction
por: Bagci, Enise, et al.
Publicado: (2015)

Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases
por: Valenzuela, Allan, et al.
Publicado: (2021)

Does intrauterine crowding affect locomotor development? A comparative study of motor performance, neuromotor maturation and gait variability among piglets that differ in birth weight and vitality
por: Vanden Hole, Charlotte, et al.
Publicado: (2018)

Does intrauterine crowding affect the force generating capacity and muscle composition of the piglet front limb?
por: Vanden Hole, Charlotte, et al.
Publicado: (2019)

Glucose and glycogen levels in piglets that differ in birth weight and vitality
por: Vanden Hole, Charlotte, et al.
Publicado: (2019)

Investigation of Coronal Leakage of Root Fillings after Smear Layer Removal with EDTA or Er,Cr:YSGG Laser through Capillary Flow Porometry
por: Vergauwen, Tom Edgard Maria, et al.
Publicado: (2014)

How does intrauterine crowding affect locomotor performance in newborn pigs? A study of force generating capacity and muscle composition of the hind limb
por: Vanden Hole, Charlotte, et al.
Publicado: (2018)

Microarray-Based Transcriptomic Analysis of Differences between Long-Term Gregarious and Solitarious Desert Locusts
por: Badisco, Liesbeth, et al.
Publicado: (2011)

Biotransformation of nitric oxide.
por: Yoshida, K, et al.
Publicado: (1987)

Fungal biotransformation of ezetimibe
por: Pervaiz, Irfan, et al.
Publicado: (2014)

Preterm Birth Affects Early Motor Development in Pigs
por: Vanden Hole, Charlotte, et al.
Publicado: (2021)

Dispositions : a debate /
por: Armstrong, D. M. (David Malet), 1926-
Publicado: (1996)

Chronic exposure to multiple stressors alters the salivary proteome of piglets
por: Prims, Sara, et al.
Publicado: (2023)

Disposition générale
Publicado: (1966)

Representing dispositions
por: Röhl, Johannes, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_4aqauv68illaum314q5jjlt0i2