An Application of Fit Quality to Screen MDM2/p53 Protein-Protein Interaction Inhibitors

The judicious application of ligand or binding efficiency (LE) metrics, which quantify the molecular properties required to obtain binding affinity for a drug target, is gaining traction in the selection and optimization of fragments, hits and leads. Here we report for the first time the use of LE b...

Descripción completa

Detalles Bibliográficos
Autores principales: Xue, Xin, Bao, Gang, Zhang, Hai-Qing, Zhao, Ning-Yi, Sun, Yuan, Zhang, Yue, Wang, Xiao-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321222/
https://www.ncbi.nlm.nih.gov/pubmed/30513790
http://dx.doi.org/10.3390/molecules23123174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321222/
https://www.ncbi.nlm.nih.gov/pubmed/30513790
http://dx.doi.org/10.3390/molecules23123174

Ejemplares similares