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An Application of Fit Quality to Screen MDM2/p53 Protein-Protein Interaction Inhibitors
The judicious application of ligand or binding efficiency (LE) metrics, which quantify the molecular properties required to obtain binding affinity for a drug target, is gaining traction in the selection and optimization of fragments, hits and leads. Here we report for the first time the use of LE b...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321222/ https://www.ncbi.nlm.nih.gov/pubmed/30513790 http://dx.doi.org/10.3390/molecules23123174 |