Differential Effects of Posttranslational Modifications of CXCL8/Interleukin-8 on CXCR1 and CXCR2 Internalization and Signaling Properties

CXCL8 or interleukin (IL)-8 directs neutrophil migration and activation through interaction with CXCR1 and CXCR2 that belong to the family of G protein-coupled receptors (GPCRs). Naturally occurring posttranslational modifications of the NH(2)-terminal region of CXCL8 affect its biological activitie...

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Detalles Bibliográficos
Autores principales: Vacchini, Alessandro, Mortier, Anneleen, Proost, Paul, Locati, Massimo, Metzemaekers, Mieke, Borroni, Elena Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321254/
https://www.ncbi.nlm.nih.gov/pubmed/30486423
http://dx.doi.org/10.3390/ijms19123768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321254/
https://www.ncbi.nlm.nih.gov/pubmed/30486423
http://dx.doi.org/10.3390/ijms19123768

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