Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles

Suberoylanilide hydroxamic acid (SAHA) or vorinostat (VOR) is a potent inhibitor of class I histone deacetylases (HDACs) that is approved for the treatment of cutaneous T-cell lymphoma. However, it has the intrinsic limitations of low water solubility and low permeability which reduces its clinical...

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Detalles Bibliográficos
Autores principales: Meka, Anand Kumar, Jenkins, Laura J., Dàvalos-Salas, Mercedes, Pujara, Naisarg, Wong, Kuan Yau, Kumeria, Tushar, Mariadason, John M., Popat, Amirali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321298/
https://www.ncbi.nlm.nih.gov/pubmed/30562958
http://dx.doi.org/10.3390/pharmaceutics10040283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321298/
https://www.ncbi.nlm.nih.gov/pubmed/30562958
http://dx.doi.org/10.3390/pharmaceutics10040283

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